Autoclavable bench-scale bioreactors / fermentors - F1 Series

Bionet F1 Laboratory Bioreactor – Versatility and Next-Generation Bioprocessing Technology

The Bionet F1 laboratory bioreactor is a modern, versatile, and highly reliable system designed for both cell culture and microbial fermentation. This automated bioreactor was developed to meet the diverse R&D requirements of biotechnology and biopharmaceutical industries, and it is equally suited for use in agriculture and food production. Combining advanced bioprocessing technologies with maximum flexibility, the F1 bioreactor allows for the seamless execution of multiple process types — from delicate cell cultures to intensive microbial fermentations — while ensuring top-tier quality and full GMP compliance.

Technical Specifications (Selected Highlights)

• Working volume: 0.5 to 10 L
• Temperature range: 10–80°C
• Agitation: Top-mounted agitator (Rushton, pitched-blade); 80–2000 rpm
• Power supply: 230 V / 120 V / 100 V, max 2500 W
• Gas control: 1 to 4 MFCs (Air, O₂, CO₂, N₂)
• Pumps: 3 standard (expandable to 7)

ROSITA 2.0 – Advanced Process Control Software

• Automated control of key parameters (pH, DO, OD, temperature, liquid level)
• User-defined and programmable control loops
• Real-time soft sensors and advanced data analytics
• Customizable interface and live bioreactor visualization

Key Advantages of the Bionet F1 Bioreactor

• Broad application range – supports microbial fermentation, mammalian and plant cell culture, airlift, photobioreactors, and patented 2D rocking motion
• Vessel compatibility – compatible with both reusable glass vessels and single-use bags
• Single or TWIN configuration – enables parallel processing with two independent vessels
• GMP compliant – ready for production environments

Plug&Play Architecture and Scalable Design

The F1 bioreactor platform is fully modular and expandable based on user needs:

• bVSP – Variable Speed Pump Module

Expands the standard pump configuration (2 fixed-speed + 1 variable-speed) with additional variable-speed pumps. Ideal for implementing complex dosing strategies (fed-batch, perfusion) and managing multiple additions or withdrawals (e.g., continuous sampling or harvesting) with customizable feed/bleed profiles.

• bScale – Laboratory/Industrial Weighing Module

Enables real-time weight monitoring of the vessel or feed containers. Essential for precision media addition, evaporation tracking, or continuous operation control. Compatible with various balance types and brands.

• bBreath – Exhaust Gas Analysis Module

Continuously monitors O₂ and CO₂ concentrations in the exhaust gas, providing valuable metabolic indicators. This data enables real-time adjustments to improve process productivity and product quality by tracking culture respiration intensity.

• Gas Module Expansion

The standard F1 comes with a single MFC (Mass Flow Controller) for sparger-based gas delivery. The expanded module supports up to four independent MFCs, allowing accurate mixing of up to four gases (Air, O₂, CO₂, N₂) delivered via sparger and/or overlay. This setup provides full environmental control — from maintaining dissolved oxygen levels to pH regulation via CO₂ addition. All gas components integrate seamlessly with the automation system for centralized control.

On-site expansion: All modules can be installed directly in your lab without returning the unit to the factory.

A Scalable Bioreactor for R&D and Beyond

The Bionet F1 laboratory bioreactor is the ideal solution for research and production teams seeking a flexible, scalable, and fully automated platform to execute advanced bioprocesses. Whether you're scaling up a novel cell culture line, optimizing microbial fermentation, or validating GMP-compliant pilot runs, the F1 delivers unmatched versatility and performance in a compact, future-ready system.