Lab-scale tangential flow filtration system - M1

The M1 TFF unit is a compact system for concentration / purification of biomolecules and biomass from fermentation or cell culturing broths at lab scale through TFF and/or for evaluating the TFF potential of their processes. TFF could be the most suitable technology for the downstream of your process for products including vaccines, enzymes, monoclonal antibodies or recombinant proteins.

The M1 allows for a deep study of the impact of all relevant parameters in terms of the most optimal configuration of the equipment and its operation, crucial in the R&D and optimization stages. Experiments at this stage include:

• Selection of the optimal membrane material and pore size
• Generation of filtrate flux and transmembrane pressure (TMP) curves at different feed circulation flow rates, to elucidate the most optional operating conditions (i.e. flow rate, TMP, filtrate flux)
• Calculation of the achievable concentration factor
• Selection of the most optimal working temperatures